Why is placentation abnormal in preeclampsia?
نویسندگان
چکیده
منابع مشابه
Abnormal placentation and the syndrome of preeclampsia.
Preeclampsia, particularly the severe cases that occur early in pregnancy, is associated with defects in the (placental) cytotrophoblast differentiation pathway that leads to uterine invasion. At a morphologic level, interstitial invasion often is shallow. Perhaps more significantly, endovascular invasion, particularly the arterial component, is rudimentary. The latter defect is thought to lead...
متن کاملHepatocyte growth factor stimulates trophoblast invasion: a potential mechanism for abnormal placentation in preeclampsia.
Hepatocyte growth factor (HGF) is a cytokine that is produced in the placental villous core and acts in a paracrine manner on trophoblasts that express the HGF receptor Met. Because HGF stimulates the invasion of many epithelial cell types, villous core HGF could regulate placental trophoblast invasion. As preeclampsia is characterized by inadequate trophoblast invasion, we investigated the hyp...
متن کاملInterleukin-11 alters placentation and causes preeclampsia features in mice.
Preeclampsia (PE) is a pregnancy-specific disorder characterized by hypertension and proteinuria after 20 wk gestation. Abnormal extravillous trophoblast (EVT) invasion and remodeling of uterine spiral arterioles is thought to contribute to PE development. Interleukin-11 (IL11) impedes human EVT invasion in vitro and is elevated in PE decidua in women. We demonstrate that IL11 administered to m...
متن کاملMRI in the diagnosis and surgical management of abnormal placentation.
OBJECTIVE To determine the usefulness of placental magnetic resonance imaging (MRI) in the diagnosis and surgical management of abnormal placentation. DESIGN Retrospective follow-up. SETTING Buenos Aires, Argentina. POPULATION 547 pregnant women. METHODS In all cases, a direct and reliable description of abnormal placentation features was obtained by the operating surgeon. Placental MRI...
متن کاملAbnormal Placentation: Placenta Previa, Vasa Previa, and Placenta Accreta.
Placental disorders such as placenta previa, placenta accreta, and vasa previa are all associated with vaginal bleeding in the second half of pregnancy. They are also important causes of serious fetal and maternal morbidity and even mortality. Moreover, the rates of previa and accreta are increasing, probably as a result of increasing rates of cesarean delivery, maternal age, and assisted repro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Obstetrics and Gynecology
سال: 2015
ISSN: 0002-9378
DOI: 10.1016/j.ajog.2015.08.042